Criticalkare Pharma

Rojuzda 25mg injection contains an active component as Luspatercept. It is a medication that has been developed for the treatment of certain types of anemia. Specifically, it treats anemia associated with two rare blood disorders: beta-thalassemia and myelodysplastic syndromes (MDS). Beta-thalassemia is an inherited blood disorder that affects the production of hemoglobin, the protein responsible for carrying oxygen in red blood cells. Myelodysplastic syndromes (MDS) are a group of bone marrow disorders characterized by ineffective blood cell production. One of the primary benefits of this medication is its ability to reduce the frequency of blood transfusions in patients with anemia associated with beta-thalassemia and MDS.
Rojuzda 25mg injection should not be used in individuals who have a known hypersensitivity or allergic reaction to the medication or any of its components. It may increase the risk of blood clot formation. Suppose you have a history of blood clots or are at an increased risk for clotting disorders. In that case, your healthcare provider should carefully evaluate the potential risks and benefits of Rojuzda 25mg injection treatment. Tell your healthcare provider before taking it if you have any other medical conditions or are undergoing treatments.

Uses
Beta-thalassemiaMyelodysplastic syndromes

Storage
Stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).Keep away from moisture, heat, and light.It should not be frozen.

Side Effects
Blood clotsHypertension (high blood pressure)StrokeHeart attackVenous thromboembolism (blood clot in a vein)Thrombosis (blood clotting disorder)Embolism (blockage of blood vessels by a clot or other substance)Hemorrhage (excessive bleeding)Allergic reactions (rare, but may include rash, itching, swelling, severe dizziness, or difficulty breathing)HeadacheFatigueDizzinessNauseaJoint painBone painMuscle painInjection site reactions (e.g., pain, redness, swelling)

Avastin 400mg Injection is an anticancer medicine consisting of the active ingredient Bevacizumab. This medicine is developed to prevent the growth of tumors. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube, or primary peritoneal cancer. Use effective birth control during the treatment and for at least six months after the last dose. Avastin 400mg Injection is not recommended for adolescents and children under the age of 18. Discuss with your doctor about the preservation of ovaries if you are planning for pregnancy in the near future, as this medicine may cause fertility issues in women. It would be best to avoid breastfeeding your baby, as this medicine may interfere with growth and development.
Avastin 400mg Injection is often administered in combination with other chemotherapy agents. Constipation, appetite loss, runny nose, fever, skin problems, and weight loss are common side effects of Avastin 400mg Injection. Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, or heart problems. This medicine should not be taken for 28 days before and after surgery, as it is associated with poor wound healing and high bleeding complications. It is advised to report to your doctor if you have any dental issues that require surgery before taking this medicine. In case you develop any visual changes or confusion, report to your doctor to prevent complications.

Uses
Glioblastoma multiforme (brain cancer)Persistent, recurrent, or metastatic breast cancerMetastatic cervical cancerAdvanced kidney cancerMetastatic colorectal cancerAdvanced non-small-cell lung cancerLiver Cancer—Hepatocellular carcinomaCancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Storage
Store Avastin 400mg Injection at 2°C to 8°C.
Do not freeze or shake.

Side Effects
HeadacheVision changesConfusionSevere allergic reactionsHigh Blood pressureDelayed wound healing following surgeryProtein in urineSevere infectionsBlood clots in arteries and blood vessels of lungsGut perforationNosebleeds and bleeding riskHeart problems with an increase in heart rateMouth sores, drynessShortness of breathNumbness in hands or feetWeakness and lack of energyDiarrhoea, nausea, vomiting, abdominal painConstipationLoss of appetiteWeight lossChanges in taste and speechDecrease in counts of white blood cellsFeverDry skinBack pain

Rojuzda 75mg injection contains an active component as luspatercept. It is a medication that has been developed for the treatment of certain types of anemia. Specifically, it treats anemia associated with two rare blood disorders: beta-thalassemia and myelodysplastic syndromes (MDS). Beta-thalassemia is an inherited blood disorder that affects the production of hemoglobin, the protein responsible for carrying oxygen in red blood cells. Myelodysplastic syndromes (MDS) are a group of bone marrow disorders characterized by ineffective blood cell production. One of the primary benefits of this medication is its ability to reduce the frequency of blood transfusions in patients with anemia associated with beta-thalassemia and MDS.
Rojuzda 75mg injection should not be used in individuals who have a known hypersensitivity or allergic reaction to the medication or any of its components. It may increase the risk of blood clot formation. Suppose you have a history of blood clots or are at an increased risk for clotting disorders. In that case, your healthcare provider should carefully evaluate the potential risks and benefits of Rojuzda 75mg injection treatment. Tell your healthcare provider if you have any other medical conditions or are undergoing treatments before taking it.

Uses
Beta-thalassemiaMyelodysplastic syndromes

Storage
Stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).Keep away from moisture, heat, and light.It should not be frozen.

Side Effects
Blood clotsHypertension (high blood pressure)StrokeHeart attackVenous thromboembolism (blood clot in a vein)Thrombosis (blood clotting disorder)Embolism (blockage of blood vessels by a clot or other substance)Hemorrhage (excessive bleeding)Allergic reactions (rare, but may include rash, itching, swelling, severe dizziness, or difficulty breathing)HeadacheFatigueDizzinessNauseaJoint painBone painMuscle painInjection site reactions (e.g., pain, redness, swelling)

Adsunib 12.5mg Capsule consists of the active ingredient Sunitinib. It is classified as a tyrosine kinase inhibitor, which means that it works by blocking certain enzymes called tyrosine kinases that are involved in the growth and spread of cancer cells. This medication is used to treat gastrointestinal stromal tumors (GIST), a rare cancer that can start anywhere in the gastrointestinal tract. This medication is also used to treat advanced kidney cancer and pancreatic cancer called pancreatic neuroendocrine tumors (PNET). Cancer is a disorder in which abnormal cells grow in an uncontrolled manner. It is not recommended for people under 18. 
Before taking Adsunib 12.5mg Capsule, it is important to discuss with the physician if you have blood conditions, heart problems, liver disorders, kidney problems, skin disorders, diabetes, seizures, or thyroid disorders. Also, inform if you have recently had surgery or are about to have surgery. Tell your doctor if you are hypertensive because this medication sometimes causes hypertension as a side effect. Avoid taking grapefruit in any form during the treatment with Adsunib 12.5mg Capsule. Check with your dentist if you have any problems in the mouth, such as mouth pain, swelling, or sores inside the mouth, before starting treatment.

Uses
Renal cell carcinoma (RCC)Gastrointestinal stromal tumors (GIST)Pancreatic neuroendocrine tumors (PNET)Medullary thyroid cancerCertain kidney cancers

Storage
Adsunib 12.5mg Capsules should be stored at room temperature, between 68°F and 77°F (20°C and 25°C).Keep it in the original package.Protected from moisture, light, and heat.

Side Effects
Heart failure or heart attackElevated liver function tests.Liver failureProteinuriaAcute kidney injuryInterstitial lung disease (inflammation of lung walls)Pulmonary arterial hypertensionGastrointestinal perforation or fistulaHaemorrhage (bleeding)Hypothyroidism (low thyroid function)Hypoglycemia (low blood sugar)FatigueNausea and vomitingDiarrhoeaLoss of appetiteHand-foot syndromeSkin discoloration or rashHigh blood pressureHeadacheHair lossChanges in tasteDry skin or itchingNosebleeds

Adsunib 25mg Capsule consists of the active ingredient Sunitinib. It is classified as a tyrosine kinase inhibitor, which means that it works by blocking certain enzymes called tyrosine kinases that are involved in the growth and spread of cancer cells. This medication is used to treat gastrointestinal stromal tumors (GIST), a rare cancer that can start anywhere in the gastrointestinal tract. This medication is also used to treat advanced kidney cancer and pancreatic cancer called pancreatic neuroendocrine tumors (PNET). Cancer is a disorder in which abnormal cells grow in an uncontrolled manner. It is not recommended for people under 18. 
Before taking Adsunib 25mg Capsule, it is important to discuss with the physician if you have blood conditions, heart problems, liver disorders, kidney problems, skin disorders, diabetes, seizures, or thyroid disorders. Also, inform if you have recently had surgery or are about to have surgery. Tell your doctor if you are hypertensive because this medication sometimes causes hypertension as a side effect. Avoid taking grapefruit in any form during the treatment with Adsunib 25mg Capsule. Check with your dentist if you have any problems in the mouth, such as mouth pain, swelling, or sores inside the mouth, before starting treatment.

Uses
Renal cell carcinoma (RCC)Gastrointestinal stromal tumors (GIST)Pancreatic neuroendocrine tumors (PNET)Medullary thyroid cancerCertain kidney cancers

Storage
Adsunib 25mg Capsule should be stored at room temperature, between 68°F and 77°F (20°C and 25°C).Keep it in the original package.Protected from moisture, light, and heat.

Side Effects
Heart failure or heart attackElevated liver function tests.Liver failureProteinuriaAcute kidney injuryInterstitial lung disease (inflammation of lung walls)Pulmonary arterial hypertensionGastrointestinal perforation or fistulaHaemorrhage (bleeding)Hypothyroidism (low thyroid function)Hypoglycemia (low blood sugar)FatigueNausea and vomitingDiarrhoeaLoss of appetiteHand-foot syndromeSkin discoloration or rashHigh blood pressureHeadacheHair lossChanges in tasteDry skin or itchingNosebleeds

Adsunib 50mg Capsule consists of the active ingredient Sunitinib. It is classified as a tyrosine kinase inhibitor, which means that it works by blocking certain enzymes called tyrosine kinases that are involved in the growth and spread of cancer cells. This medication is used to treat gastrointestinal stromal tumors (GIST), a rare cancer that can start anywhere in the gastrointestinal tract. This medication is also used to treat advanced kidney cancer and pancreatic cancer called pancreatic neuroendocrine tumors (PNET). Cancer is a disorder in which abnormal cells grow in an uncontrolled manner. It is not recommended for people under 18. 
Before taking Adsunib 50mg Capsule, it is important to discuss with the physician if you have blood conditions, heart problems, liver disorders, kidney problems, skin disorders, diabetes, seizures, or thyroid disorders. Also, inform if you have recently had surgery or are about to have surgery. Tell your doctor if you are hypertensive because this medication sometimes causes hypertension as a side effect. Avoid taking grapefruit in any form during the treatment with Adsunib 50mg Capsule. Check with your dentist if you have any problems in the mouth, such as mouth pain, swelling, or sores inside the mouth, before starting treatment.

Uses
Renal cell carcinoma (RCC)Gastrointestinal stromal tumors (GIST)Pancreatic neuroendocrine tumors (PNET)Medullary thyroid cancerCertain kidney cancers

Storage
Adsunib 50mg Capsule should be stored at room temperature, between 68°F and 77°F (20°C and 25°C).Keep it in the original package.
Protected from moisture, light, and heat.

Side Effects
Heart failure or heart attackElevated liver function tests.Liver failureProteinuriaAcute kidney injuryInterstitial lung disease (inflammation of lung walls)Pulmonary arterial hypertensionGastrointestinal perforation or fistulaHaemorrhage (bleeding)Hypothyroidism (low thyroid function)Hypoglycemia (low blood sugar)FatigueNausea and vomitingDiarrhoeaLoss of appetiteHand-foot syndromeSkin discoloration or rashHigh blood pressureHeadacheHair lossChanges in tasteDry skin or itchingNosebleeds

Anvimo 480mg Tablet is an antiviral medication containing letermovir as its active ingredient. It belongs to the pharmacological class of antiviral agents and is specifically classified under cytomegalovirus (CMV) DNA terminase inhibitors. Anvimo 480mg Tablet is primarily used to prevent cytomegalovirus (CMV) infection in patients who have recently undergone an allogeneic hematopoietic stem cell transplant (HSCT) and are at a higher risk of CMV reactivation.
Anvimo 480mg Tablet works by inhibiting the CMV DNA terminase complex, which is crucial for viral replication. It is typically prescribed for CMV-seropositive adult patients post-transplant to reduce the likelihood of viral complications. However, the medication is not a treatment for existing CMV infections.
Patients taking this medication should follow strict safety precautions. It is contraindicated in individuals with known hypersensitivity to letermovir or any of its excipients. Additionally, it is not recommended for use with certain medications due to serious drug interactions. Healthcare professionals advise caution in pregnant or breastfeeding women, individuals with liver impairment, and those consuming alcohol.
UsesAnvimo 480mg Tablet is FDA-approved for the prevention of cytomegalovirus (CMV) infection in adult patients who:
Have undergone allogeneic hematopoietic stem cell transplantation (HSCT)Are CMV-seropositive, meaning they have previously been exposed to the virusThis medication is used prophylactically and should not be used to treat an active CMV infection.

Storage
Keep Anvimo 480mg Tablet at room temperature (20-25°C), away from moisture and direct sunlight.Do not double-dose.Seek immediate medical attention if an overdose occurs. Symptoms may include severe nausea or irregular heartbeat.
Side Effects
NauseaFatigueHeadacheDiarrheaAbdominal painIrregular heartbeatSwelling in legs or feetUnexplained bleeding or bruisingSevere allergic reactions (rash, breathing difficulty)

Brukinsa 80mg Capsule is a prescription medicine used to treat certain types of blood cancers. It contains Zanubrutinib, which belongs to a class of drugs called BTK inhibitors. These medicines work by blocking a protein that helps cancer cells grow and survive, so they slow down or stop the spread of cancer in the body.
Doctors usually prescribe Brukinsa 80mg Capsule to people who’ve already had other treatments for blood cancer. It’s taken by mouth and usually comes as a capsule. While it can be effective, it’s not suitable for everyone. People with serious liver problems, certain heart issues, or women who are pregnant or breastfeeding should not use this medicine unless a doctor says it’s safe.
Before starting the treatment, your doctor will do some blood tests to make sure the medicine is right for you. They’ll also check your health regularly during the treatment to make sure everything stays on track.

Uses
Mantle Cell Lymphoma (MCL) – in adults who’ve had at least one previous treatment
Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL)
Waldenström’s Macroglobulinemia (WM)
Marginal Zone Lymphoma (MZL) – after treatment with an anti-CD20 medicine
Follicular Lymphoma (FL) – limited use or under review in some places

Storage
Store the medicine at room temperature (20 - 25°C), away from moisture and heat.
Keep the medicine out of reach of children and pets.
Do not share your medication with others, even if they have similar symptoms.

Side Effects
Diarrhea
Muscle pain
Cough
Rash
Low white blood cell count
Tiredness
Bruising easily
Serious infections (fever, chills, shortness of breath)
Bleeding or blood in stool/urine
Irregular heartbeat or chest pain
Liver problems (yellowing of skin or eyes)Severe allergic reactions (swelling, rash, difficulty breathing)

Akynzeo Injection is an anti-emetic medication containing a fixed-dose combination of two active ingredients, such as fosnetupitant and palonosetron. Fosetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist.  This medication is used to prevent chemotherapy-induced nausea and vomiting (CINV). It is prescribed to help cancer patients to better tolerate their chemotherapy treatments by reducing the likelihood of these distressing side effects and is also used to control postoperative nausea and vomiting.
The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. If you have liver problems or renal impairment, discuss this with your physician. Dosing adjustments may be necessary in such cases. There is a potential risk of serotonin syndrome when Akynzeo Injection is combined with other serotonergic medications. Serotonin syndrome can cause symptoms such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. Inform your physician about all medications, including antidepressants and other serotonergic drugs, that you are taking.
The safety and efficacy of Akynzeo Injection in pediatric patients have not been established. It is primarily intended for use in adults. It is unsafe to administer this drug to pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine. It is unclear whether this drug passes into breast milk for breastfeeding women, and consulting a doctor for guidance would be a better choice.

Uses
Chemotherapy-induced nausea and vomiting.Postoperative nausea and vomiting.

Storage
Store Akynzeo Injection below 25°C.Do not freeze.

Side Effects
Allergic reactionsHivesSwollen faceBreathing troubleChest painHeadacheFatigueDizzinessAbdominal pain

Imjudo 300mg Injection 15ml is an advanced immunotherapy used in the treatment of certain types of cancer. It contains Tremelimumab, a type of monoclonal antibody that belongs to the pharmacological class called immune checkpoint inhibitors. This medicine is primarily used in combination with other cancer therapies to enhance the body’s immune response against cancer cells. It is classified under the therapeutic category of anti-cancer drugs and is commonly prescribed for conditions like liver cancer and mesothelioma.
While Imjudo 300mg Injection 15ml has shown promising results in clinical settings, it must be used with caution. It is not recommended for individuals with severe autoimmune diseases or a history of organ transplant, as it may overstimulate the immune system. Imjudo 300mg Injection 15ml should always be administered under the supervision of an oncology specialist. Patients must be regularly monitored during treatment due to potential risks, including immune-related reactions affecting the lungs, liver, or endocrine glands. Pregnant or breastfeeding women should avoid this medication unless clearly advised by their doctor.

Uses
Unresectable hepatocellular carcinoma (a type of liver cancer), in combination with durvalumab.Malignant pleural mesothelioma (a rare cancer affecting the lining of the lungs), in combination therapies.

Storage
Store in a refrigerator between 2°C to 8°C. Do not freeze.Do not shake the vial. Protect from light.

Side Effects
Tiredness or fatigueDiarrhoea or abdominal painSkin rash or itchingLoss of appetiteJoint or muscle painSevere diarrhoea or colitisBreathing difficulty or chest tightness (signs of pneumonitis)Yellowing of the skin or eyes (possible liver issues)Hormonal problems like thyroid imbalanceEye inflammation or vision problems

Akynzeo capsule contains the active ingredients Netupitant and palonosetron. It is an antiemetic drug belonging to the class of 5-HT3  receptor antagonists. It is used to prevent and treat nausea, vomiting, or sickness caused by cancer treatments such as chemotherapy or radiotherapy or after surgery. Nausea is characterized by stomach pain and the urge to vomit.
The common side effects that are likely to occur with Akynzeo 300mg/0.5mg Capsule are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. It is given right away or later with anticancer medicines. It is usually given up to 24 hours while recovering from anesthesia after surgery. 
Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals in your blood (such as magnesium and potassium). This medicine should not be used if you are allergic to this drug. Tell your physician about all the medications you have been taking recently, including herbal medicines and supplements, before taking the Akynzeo capsule.

Uses
Postoperative nausea and vomiting.Chemotherapy-induced nausea and vomiting.

Storage
Store the Akynzeo capsule in the original package at room temperature (25°C).
Do not freeze.

Side Effects
HivesSwollen faceBreathing troubleChest painHeadacheFatigueDizzinessAbdominal pain

Praxbind 2.5gm injection is an antidote that contains the active ingredient called Idarucizumab. It is a special medicine that can reverse the effects of another medication called dabigatran. Dabigatran is a blood thinner that prevents blood clots by targeting a certain substance in the body. It quickly captures Dabigatran and reverses its effects, restoring normal blood clotting. This medicine is used in adults to rapidly reverse its effects in emergencies, including surgeries and life-threatening bleeding. Anticoagulant therapies are initiated to prevent and treat blood clot formation in conditions like thromboembolism.

Do not take Praxbind 2.5gm injection if you are allergic to Idarucizumab or any of its ingredients.  Before starting the treatment, inform your physician if you have hereditary fructose intolerance. Your doctor will consider this information before administering the medicine. There is currently no available information regarding the use of this medicine in children. Each dose of this medicine contains 50 mg of sodium, so before you start the treatment, if you are on the sodium control diet. Notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding.

Uses of Praxbind 2.5gm Injection

The reversal of anticoagulant effects is needed in

• Emergency or urgent surgical procedures
• Life-threatening or uncontrolled bleeding

Therapeutic Effects of Praxbind 2.5gm Injection

Praxbind 2.5gm injection works by binding tightly to dabigatran, the blood thinner medicine. This binding neutralizes the effects of dabigatran, allowing the blood to clot normally. It acts as a rapid antidote, quickly reversing the blood-thinning effects of dabigatran in emergencies.

Interaction of Praxbind 2.5gm Injection with other drugs

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, supplements, and herbal products. Certain medications like fampridine interact with Praxbind 2.5gm injection and reduce their effectiveness by causing undesirable side effects. 

More Information about Praxbind 2.5gm Injection

• Store Praxbind 2.5gm injection at (2°C – 8°C). Do not freeze the medicine.
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets.
• Always look for the expiration date before consuming it.

How to consume Praxbind 2.5gm Injection

Praxbind 2.5gm injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered in the vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.

Side Effects of Praxbind 2.5gm Injection

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Praxbind 2.5gm injection  is generally safe to consume and is not associated with significant side effects. However, if you experience any unfamiliar side effects, consult your dietician for advice.